Cortisol and social stressors in children with fragile X: a pilot study.

@article{Wisbeck2000CortisolAS,
  title={Cortisol and social stressors in children with fragile X: a pilot study.},
  author={Jacob Wisbeck and Lynne C. Huffman and Lisa M Freund and Megan R. Gunnar and Elysia Poggi Davis and Allan L. Reiss},
  journal={Journal of developmental and behavioral pediatrics : JDBP},
  year={2000},
  volume={21 4},
  pages={278-82}
}
Evidence of neuroendocrine dysfunction, behavioral features of social anxiety and avoidance, and neuroanatomical abnormalities suggest that abnormal hypothalamic-pituitary-adrenal (HPA) function may be a component of the fragile X (fra X) syndrome. In this preliminary study, salivary cortisol levels of males (n = 8, mean age = 13.5 yr) and females (n = 7, mean age = 13.9 yr) with the fra X full mutation were studied for 3 days. Day 1 was an experimental day, during which subjects experienced a… CONTINUE READING