Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice.

@article{Yamano2000CorticotropinreleasingHR,
  title={Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice.},
  author={Mayumi Yamano and Hidenobu Yuki and Shuichi Yasuda and K. Miyata},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={292 1},
  pages={181-7}
}
Depression-like behavior induced by YM643, a consensus interferon-alpha (IFN-alpha), was evaluated with the tail-suspension test in mice and compared with depression-like behavior induced by sumiferon, a natural IFN-alpha. To investigate the mechanism of IFN-alpha-induced depression-like behavior, the effects of the tricyclic antidepressant imipramine, the cyclooxygenase inhibitor indomethacin, the opioid receptor antagonist naloxone, and the selective corticotropin-releasing hormone receptor… CONTINUE READING