Corticotropin-releasing hormone physiology

  title={Corticotropin-releasing hormone physiology},
  author={Joseph A. Majzoub},
Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adrenal (HPA) axis. Major functions of the HPA include: (i) influencing fetal development of major organ… CONTINUE READING


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