Corticotropin-releasing hormone-mediated pathway of leptin to regulate feeding, adiposity, and uncoupling protein expression in mice.

@article{Masaki2003CorticotropinreleasingHP,
  title={Corticotropin-releasing hormone-mediated pathway of leptin to regulate feeding, adiposity, and uncoupling protein expression in mice.},
  author={Takayuki Masaki and Go Yoshimichi and Seiichi Chiba and Tohru Yasuda and Hitoshi Noguchi and Tetsuya Kakuma and Toshiie Sakata and Hironobu Yoshimatsu},
  journal={Endocrinology},
  year={2003},
  volume={144 8},
  pages={3547-54}
}
To examine the functional role of CRH in the regulation of energy homeostasis by leptin, we measured the effects of the CRH antagonist, alpha-helical CRH 8-41 (alphaCRH) on a number of factors affected by leptin activity. These included food intake, body weight, hypothalamic c-fos-like immunoreactivity (c-FLI), weight and histological characterization of white adipose tissue, and mRNA expressions of uncoupling protein (UCP) in brown adipose tissue (BAT) in C57Bl/6 mice. Central infusion of… CONTINUE READING
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Targeted disruption of histamine H1 receptor attenuated regulatory effect of leptin in feeding and UCP family expression in mice

  • T Masaki, H Yoshimatsu, S Chiba, T Watanebe, T Sakata
  • Diabetes
  • 2001

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