Corticotropin-releasing hormone inhibition of gonadotropin release and the effect of opioid blockade.

@article{Barbarino1989CorticotropinreleasingHI,
  title={Corticotropin-releasing hormone inhibition of gonadotropin release and the effect of opioid blockade.},
  author={Alessandro Barbarino and Laura de Marinis and Anna Tofani and Silvia Della Casa and Calogero D'Amico and Antonio Mancini and Salvatore Maria Corsello and Rosa Sciuto and Angela Barini},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1989},
  volume={68 3},
  pages={523-8}
}
We studied the inhibitory effect of exogenous CRH on pulsatile gonadotropin secretion and the role of endogenous opioid peptides in this phenomenon in normal women. To do so, we infused human CRH (100 micrograms/h for 3 h) into 15 normal women during the midluteal phase of their menstrual cycle and studied its effect on both basal (10 women) and GnRH-stimulated (5 women) plasma gonadotropin levels. CRH infusion induced a significant decrease in plasma LH and FSH levels in all women. The decline… CONTINUE READING

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