Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis.

  title={Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis.},
  author={Yutaka Kawahito and Hajime Sano and Shigehiko Mukai and Ken-ichi Asai and Satoshi Kensuke Kimura and Yuichi Yamamura and Hirotoshi Kato and George P. Chrousos and Ronald L. Wilder and Masashi Kondo},
  volume={37 4},
Corticotropin releasing hormone (CRH) is a key hormone in integrated response to stress, acting as the major regulator of the hypothalamic-pituitary-adrenal axis. Recently, local production of CRH has been detected in normal human colonic enterochromaffin cells. CRH is locally secreted in granulomatous and arthritic tissues in rats and humans, where it seems to act as a local proinflammatory agent. To find out if CRH is present in colonic tissues of patients with ulcerative colitis, this study… CONTINUE READING
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Local secretion of corticotropin releasing factor by enterochromaffin cells in human colon

  • P Chomczynski, N Sacchi
  • Gastroenterology
  • 1994

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