Corticotropin-releasing hormone excites myenteric neurons in the guinea-pig small intestine.

  title={Corticotropin-releasing hormone excites myenteric neurons in the guinea-pig small intestine.},
  author={Menachem Hanani and Jackie D. Wood},
  journal={European journal of pharmacology},
  volume={211 1},
The electrophysiological actions of corticotropin-releasing hormone (CRH) on myenteric neurons from the guinea-pig ileum were studied by intracellular microelectrode recording. CRH, when applied by micropressure ejection or in the medium (0.2-20 nM) evoked prolonged depolarization in 21 of 42 S/type 1 neurons and in 28 of 40 AH/type 2 neurons. These responses were associated with increased input resistance and augmented excitability. The post-spike hyperpolarization in AH/type 2 cells was… CONTINUE READING
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