Corticotropin releasing hormone, interleukin-1 alpha, and tumor necrosis factor-alpha share characteristics of stress mediators.

@article{Bianchi1991CorticotropinRH,
  title={Corticotropin releasing hormone, interleukin-1 alpha, and tumor necrosis factor-alpha share characteristics of stress mediators.},
  author={Mauro Bianchi and Paola Sacerdote and L D Locatelli and Paolo Mantegazza and Alberto Emilio Panerai},
  journal={Brain research},
  year={1991},
  volume={546 1},
  pages={139-42}
}
Interleukin-1 alpha and tumor necrosis factor-alpha induce an increase in pain thresholds in the rat. We now show that also the corticotropin releasing hormone induces an analgesic effect that, similarly to what is observed with the two cytokines, is not reversible by naloxone. Moreover, we also show that after the administration of interleukin-1 alpha, tumor necrosis factor-alpha, and corticotropin releasing hormone, naloxone becomes analgesic itself. A similar observation was also made in the… CONTINUE READING

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