Corticotropin releasing factor stimulation of protein carboxylmethylation in mouse pituitary tumor cells.

@article{Heisler1983CorticotropinRF,
  title={Corticotropin releasing factor stimulation of protein carboxylmethylation in mouse pituitary tumor cells.},
  author={Seymour Heisler and Vivian Hook and Julius Axelrod},
  journal={Biochemical pharmacology},
  year={1983},
  volume={32 7},
  pages={
          1295-9
        }
}
A putative role for the protein carboxylmethylase (PCM) enzyme has been suggested in exocytotic secretion. The involvement of 3H-methyl incorporation into protein carboxylmethyl esters during corticotropin releasing factor (CRF)-induced ACTH secretion from AtT-20/D16-16 mouse pituitary cells was investigated. Protein carboxylmethylation and ACTH secretion both increased as a function of extracellular CRF concentration, and both processes were temporally parallel up to 60 min incubation. The… CONTINUE READING
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