Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats.

@article{Lu2000CorticotropinreleasingFR,
  title={Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats.},
  author={Lin Lu and Xiangshi Ceng and Mian Qing Huang},
  journal={Neuroreport},
  year={2000},
  volume={11 11},
  pages={2373-8}
}
The possible effect of different corticotropin-releasing factor receptor (CRFR) antagonists (alpha-helical CRF, CP-154,526 and AS-30) on the maintenance and reactivation of morphine-conditioned place preference (CPP) induced by morphine or footshock stress, respectively, were investigated in rats. The results show that morphine-induced maintenance of CPP was not affected by pretreatment with any CRFR antagonists. However, morphine-induced the reactivation of CPP was significantly attenuated by… CONTINUE READING

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