Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling

Abstract

Several neuropsychiatric and neurodegenerative disorders share stress as a risk factor and are more prevalent in women than in men. Corticotropin-releasing factor (CRF) orchestrates the stress response, and excessive CRF is thought to contribute to the pathophysiology of these diseases. We previously found that the CRF1 receptor (CRF1) is sex biased whereby… (More)
DOI: 10.1038/mp.2016.185

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