Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting.

@article{Stengel2009CorticotropinreleasingFM,
  title={Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting.},
  author={Andreas Stengel and Miriam Goebel and Mulugeta Million and Mary P. Stenzel-Poore and Peter Kobelt and Hubert M{\"o}nnikes and Yvette F. Tach{\'e} and Lixin Wang},
  journal={Endocrinology},
  year={2009},
  volume={150 1},
  pages={153-60}
}
Corticotropin-releasing factor (CRF) overexpressing (OE) mice are a genetic model that exhibits features of chronic stress. We investigated whether the adaptive feeding response to a hypocaloric challenge induced by food deprivation is impaired under conditions of chronic CRF overproduction. Food intake response to a 16-h overnight fast and ip injection of gut hormones regulating food intake were compared in CRF-OE and wild type (WT) littermate mice along with brain Fos expression, circulating… CONTINUE READING
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