Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects

@article{Sautter2003CorticotropinreleasingFI,
  title={Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects},
  author={Frederic J. Sautter and Garth Bissette and Justin Wiley and Gina M Manguno-mire and Benjamin Schoenbachler and Leann Myers and Janet E Johnson and Arleen B. Cerbone and Dolores Malaspina},
  journal={Biological Psychiatry},
  year={2003},
  volume={54},
  pages={1382-1388}
}
BACKGROUND Recent studies have reported a high comorbidity between posttraumatic stress disorder (PTSD) and psychotic symptoms, and it has been hypothesized that PTSD with comorbid psychosis is a severe form of PTSD. Few studies have examined the neurobiology of PTSD with comorbid psychosis. If PTSD with secondary psychotic symptoms (PTSD-SP) is a severe form of PTSD, then it might be expected to show more extreme perturbations in the neuroendocrine patterns that characterize PTSD. METHODS… Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Psychotic features and illness severity in combat veterans with chronic posttraumatic stress disorder
TLDR
Patients with more severe psychosis ratings are likely to have more severe PTSD disease burden if psychotic features are present, and a significant interaction likely exists between PTSD, depression, and psychotic features. Expand
Psychotic symptoms in combat-related posttraumatic stress disorder.
TLDR
Psychotic symptoms can be a feature of combat-related PTSD and appear to be associated with major depression, and the association with minority status may be a function of comorbidity. Expand
Positive symptoms of psychosis in posttraumatic stress disorder
TLDR
A diagnosis of PTSD should be considered with patients who have positive symptoms in the absence of thought disorder, and some of these positive symptoms did not appear to be due to reexperience of the trauma. Expand
Psychotic features and combat‐associated PTSD
  • M. Hamner
  • Psychology, Medicine
  • Depression and anxiety
  • 1997
TLDR
In a prospective study, combat associated PTSD patients were administered clinical ratings, including the Structured Clinical Interview for DSM‐III‐R with psychotic screen (SCID‐P), Clinician Administered PTSD Scale (CAPS) and the Impact of Events Scale (IES). Expand
Psychotic features in chronic posttraumatic stress disorder and schizophrenia: comparative severity.
TLDR
Compared with patients with schizophrenia, veterans meeting DSM-IV criteria for chronic PTSD with well-defined comorbid psychotic features or chronic schizophrenia were remarkably similar with respect to not only positive but also negative symptoms. Expand
Biology of posttraumatic stress disorder.
  • R. Yehuda
  • Biology, Medicine
  • The Journal of clinical psychiatry
  • 2001
TLDR
Sensitivity of the HPA axis is consistent with the clinical picture of hyperreactivity and hyperresponsiveness in PTSD, and the reduction in cortisol levels results from an enhanced negative feedback by cortisol, which is secondary to an increased sensitivity of glucocorticoid receptors in target tissues. Expand
The corticotropin-releasing hormone test in patients with posttraumatic stress disorder
TLDR
The blunted ACTH response to CRH in PTSD patients is similar to that seen in other psychiatric disorders, such as depression, panic disorder, and anorexia nervosa. Expand
PTSD and Comorbid Psychotic Disorder: Comparison with Veterans Diagnosed with PTSD or Psychotic Disorder
TLDR
Veterans with PTSD and a comorbid psychotic disorder showed significantly higher levels of positive symptoms of psychosis, general psychopathology, paranoia, and violent thoughts, feelings, and behaviors than the other two groups. Expand
Family history study of posttraumatic stress disorder with secondary psychotic symptoms.
TLDR
PTSD with secondary psychotic symptoms was not associated with familial psychosis, suggesting it does not reflect the presence of an underlying psychotic disorder. Expand
Psychobiologic mechanisms of posttraumatic stress disorder.
TLDR
Preclinical investigations of the effects of stress on learning and memory processes suggest that fear conditioning, behavioral sensitization, and a failure of extinction may be important in the persistence and reexperiencing of traumatic memories and stressor sensitivity. Expand
...
1
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3
4
5
...