Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects

  title={Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects},
  author={Frederic J. Sautter and Garth Bissette and Justin Wiley and Gina M Manguno-mire and Benjamin Schoenbachler and Leann Myers and Janet E Johnson and Arleen B. Cerbone and Dolores Malaspina},
  journal={Biological Psychiatry},

Posttraumatic stress disorder with secondary psychotic features (PTSD-SP): Diagnostic and treatment challenges

  • Ebele CompeanM. Hamner
  • Psychology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2019

CRF serum levels differentiate PTSD from healthy controls and TBI in military veterans

The recognized enhanced feedback inhibition of the HPA axis in chronic stress supports the findings of lower CRF in PTSD patients, and suggests that reduced serum CRf in PTSD should be further investigated.

Psychotic Symptoms in Posttraumatic Stress Disorder

Clinicians should inquire about positive symptoms of psychosis not only during an initial diagnostic interview but also during follow-up sessions because many patients are embarrassed about these symptoms as well as about other facets and consequences of the traumatic experience and may need some time in a trusting relationship to disclose these symptoms.

Distinguishing schizophrenia from posttraumatic stress disorder with psychosis

A large genome-wide association study (GWAS) has identified a collection of genes associated with PTSD, and these genes overlap with those identified as increasing the risk of developing schizophrenia.

Risperidone in psychotic combat-related posttraumatic stress disorder: an open trial.

Treatment with risperidone for either 3 or 6 weeks in an open trial significantly reduced total and subscales scores on the PANSS and on the PTSD-I and CGI-S when compared to baseline scores in patients with psychotic PTSD.

Psychotic-like Experiences, Symptom Expression, and Cognitive Performance in Combat Veterans With Posttraumatic Stress Disorder

Severity of psychotic symptoms correlated with dissociation, combat exposure, and attention but not PTSD, depression, or functional health; endorsement of psychotic experiences by combat veterans with PTSD do not seem to reflect psychotic symptoms or outright malingering.

Sex-Related Predisposition to Post-Traumatic Stress Disorder Development—The Role of Neuropeptides

The roles of selected neuropeptides in the sex-related predisposition to PTSD development are presented and fear extinction in women during periods of high endogenous estradiol levels is reportedly more effective than in periods of low endogenous est radiol.



Psychotic symptoms in combat-related posttraumatic stress disorder.

Psychotic symptoms can be a feature of combat-related PTSD and appear to be associated with major depression, and the association with minority status may be a function of comorbidity.

Psychotic features and combat‐associated PTSD

  • M. Hamner
  • Psychology, Medicine
    Depression and anxiety
  • 1997
In a prospective study, combat associated PTSD patients were administered clinical ratings, including the Structured Clinical Interview for DSM‐III‐R with psychotic screen (SCID‐P), Clinician Administered PTSD Scale (CAPS) and the Impact of Events Scale (IES).

Psychotic features in chronic posttraumatic stress disorder and schizophrenia: comparative severity.

Compared with patients with schizophrenia, veterans meeting DSM-IV criteria for chronic PTSD with well-defined comorbid psychotic features or chronic schizophrenia were remarkably similar with respect to not only positive but also negative symptoms.

Biology of posttraumatic stress disorder.

  • R. Yehuda
  • Biology, Psychology
    The Journal of clinical psychiatry
  • 2001
Sensitivity of the HPA axis is consistent with the clinical picture of hyperreactivity and hyperresponsiveness in PTSD, and the reduction in cortisol levels results from an enhanced negative feedback by cortisol, which is secondary to an increased sensitivity of glucocorticoid receptors in target tissues.

Family history study of posttraumatic stress disorder with secondary psychotic symptoms.

PTSD with secondary psychotic symptoms was not associated with familial psychosis, suggesting it does not reflect the presence of an underlying psychotic disorder.

Psychobiologic mechanisms of posttraumatic stress disorder.

Preclinical investigations of the effects of stress on learning and memory processes suggest that fear conditioning, behavioral sensitization, and a failure of extinction may be important in the persistence and reexperiencing of traumatic memories and stressor sensitivity.

Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder.

The data support the hypothesis of an enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal axis in PTSD and combat veterans with PTSD suppressed cortisol to a greater extent than did combat veterans without PTSD and normal controls in response to both doses of dexamethasone.