Corticotropin-releasing factor directly mediates colonic responses to stress.

  title={Corticotropin-releasing factor directly mediates colonic responses to stress.},
  author={C. L. Williams and J. Peterson and R. Villar and T. Burks},
  journal={The American journal of physiology},
  volume={253 4 Pt 1},
A new stress model in rats produced changes in intestinal function that resemble patterns of intestinal dysfunction associated with stress in humans: small intestinal transit was inhibited, large intestinal transit was stimulated, and fecal excretion was stimulated. To evaluate the role of corticotropin-releasing factor (CRF) in mediating the effects of stress on the intestine, we studied the actions of exogenous CRF on small and large intestinal transit in the rat and characterized the effects… Expand
Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications.
  • M. Larauche, C. Kiank, Y. Taché
  • Biology, Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2009
Accumulated clinical and preclinical evidence supports in addition to the brain, a role for peripheral CRF signaling in mediating stress-induced effects on gastrointestinal sensorimotor, mucosal and immune functions, that may be components of underlying mechanisms involved in stress-related impact on inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Expand
Stress-induced gastrointestinal secretory and motor responses in rats are mediated by endogenous corticotropin-releasing factor.
The results suggest that the gastrointestinal secretory and motor responses in rats produced by stress (partial body restraint) are mediated by the endogenous release of CRF and indicate that CRF exerts its central nervous system actions on the gastrointestinal tract by a receptor-mediated event. Expand
Corticotropin-releasing factor and the brain-gut motor response to stress.
Hypersecretion of CRF in the brain may contribute to the pathophysiology of stress-related exacerbation of irritable bowel syndrome. Expand
Peripheral corticotropin-releasing factor induces diarrhea in rats: role of CRF1 receptor in fecal watery excretion.
It is demonstrated that peripheral CRF induces watery diarrhea, primarily through the activation of CRF1 receptor suggesting a possible role for these pathways in colonic responses to stress. Expand
Psychological stress-induced accelerated colonic transit in rats involves hypothalamic corticotropin-releasing factor.
Psychological stress-induced stimulation of colonic motor function in fed rats involves CRF pathways in the paraventricular nucleus of the hypothalamus or central amygdala. Expand
Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats.
It is demonstrated that CRF acts peripherally to stimulate colonic motility and thatCRF-R1 is primarily involved in mediating IP CRF/urocortin- and water avoidance stress-induced colonic motor response. Expand
Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways.
Stresslike colonic alterations induced by ip cortagine in rats and mice through restricted activation of peripheral CRF(1) receptors support a role for peripheralCRF( 1) signaling as the local arm of the colonic response to stress. Expand
Role of Corticotropin-releasing Factor Signaling in Stress-related Alterations of Colonic Motility and Hyperalgesia
These data provide a conceptual framework that sustained activation of the CRF1 system at central and/or peripheral sites may be one of the underlying basis of IBS-diarrhea symptoms. Expand
The Effect of Peripheral CRF Peptide and Water Avoidance Stress on Colonic and Gastric Transit in Guinea Pigs
Peripheral CRF peptide significantly suppressed upper GI transit and accelerated colon transit, while central CRF involved WAS stimulated only colonic transit, therefore, peripheral CRF could be utilized to establish the animal model of overlap syndrome. Expand
Role of peripheral CRF signalling pathways in stress‐related alterations of gut motility and mucosal function
  • Y. Taché, M. Perdue
  • Biology, Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2004
Convergent evidence is provided that activation of peripheral CRF receptors and mast cells are important mechanisms involved in stress‐related alterations of gut physiology. Expand