Corticotropin-releasing factor directly mediates colonic responses to stress.

@article{Williams1987CorticotropinreleasingFD,
  title={Corticotropin-releasing factor directly mediates colonic responses to stress.},
  author={C. L. Williams and J. Peterson and R. Villar and T. Burks},
  journal={The American journal of physiology},
  year={1987},
  volume={253 4 Pt 1},
  pages={
          G582-6
        }
}
A new stress model in rats produced changes in intestinal function that resemble patterns of intestinal dysfunction associated with stress in humans: small intestinal transit was inhibited, large intestinal transit was stimulated, and fecal excretion was stimulated. To evaluate the role of corticotropin-releasing factor (CRF) in mediating the effects of stress on the intestine, we studied the actions of exogenous CRF on small and large intestinal transit in the rat and characterized the effects… Expand
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