Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action.

@article{Heinrichs1992CorticotropinreleasingFA,
  title={Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action.},
  author={S C Heinrichs and Emilio Merlo Pich and Klaus A Miczek and Karen Thatcher Britton and George F. Koob},
  journal={Brain research},
  year={1992},
  volume={581 2},
  pages={190-7}
}
Introduction of a socially naive male rat into the home territory of a resident counterpart results in agonistic interactions, leading to the rapid social defeat of the intruder. Exposure to the aggressive resident produces a stress-response profile consisting of neuroendocrine activation and coping behaviors such as submission. The present studies examined the dependence of these adaptive responses on endogenous brain Corticotropin-Releasing Factor (CRF), a peptide hormone known to coordinate… CONTINUE READING

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