Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test

@article{Britton1988CorticotropinRF,
  title={Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test},
  author={Karen Thatcher Britton and Gin Hyug Lee and George F. Koob},
  journal={Psychopharmacology},
  year={1988},
  volume={94},
  pages={306-311}
}
The central nervous system stimulants corticotropin releasing factor (CRF) and amphetamine were administered in combination with the benzodiazepine ligands Ro 15-1788 and FG 7142 in order to assess their benzodiazepine agonist and antagonist receptor properties in an operant conflict test in rats. Ro 15-1788, which was without behavioral activity in this test when given alone, reversed the suppression of punished responding produced by CRF and amphetamine in a dose-dependent manner… CONTINUE READING
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The effects of FG 7142 and RO 15-1788 on the release of punished responding produced by chlordiazepoxide and ethanol in the rat

  • GF Koob, C Braestrup, K Thatcher-Britton
  • Psychopharmacology
  • 1986
Highly Influential
8 Excerpts

Ethanol antagonist , RO 15 - 4513 , is not selective for ethanol

  • KT Britton, CE Ehlers, GF Koob
  • Science
  • 1987

Ethanol antagonist, RO

  • KT Britton, CE Ehlers, GF Koob
  • 1987

A comparison of the effects of Ro 15-1788 and chlordiazepoxide on hot-plat latencies, acoustic startle and locomotor activity

  • TJ Walsh, RL McLamb, HA Tllson
  • Psychopharmacology
  • 1986
1 Excerpt

Alcohol reverses the proconflict effects of cortlcotropm releasing factor

  • KT Bratton, GF Koob
  • Regul Pept
  • 1986

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