Corticotropin-releasing factor acts via a third ventricle site to reduce exploratory behavior in rats

@article{Spadaro1990CorticotropinreleasingFA,
  title={Corticotropin-releasing factor acts via a third ventricle site to reduce exploratory behavior in rats},
  author={Francesco Spadaro and Craig W. Berridge and Helen A. Baldwin and Adrian J. Dunn},
  journal={Pharmacology Biochemistry and Behavior},
  year={1990},
  volume={36},
  pages={305-309}
}
Corticotropin-releasing factor (CRF, 20-25 ng) injected into the lateral or fourth ventricles of rats decreased exploratory behavior in the multicompartment testing chamber (MCC), as assessed by decreased mean contact times with novel stimuli. This result extends similar observations made previously in mice. To investigate the site of this action of CRF, cold cream plugs injected into the cerebral ventricles of rats were used to prevent access of the CRF to specific periventricular sites. When… CONTINUE READING

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