Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus.


Corticotropin-releasing factor (CRF) administered intraventricularly (0.5 nmol) was found to increase the discharge rates of locus coeruleus (LC) neurons in anesthetized rats. A similar effect on discharge rate was also observed during direct application of CRF to LC neurons by pressure microapplication. Intraventricular administration of CRF-OH, previously… (More)


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