Corticotropin-releasing factor (CRF) receptor type 2 in the human stomach: protective biological role by inhibition of apoptosis.

@article{Chatzaki2006CorticotropinreleasingF,
  title={Corticotropin-releasing factor (CRF) receptor type 2 in the human stomach: protective biological role by inhibition of apoptosis.},
  author={Ekaterini Chatzaki and Maria Lambropoulou and Theodoros C. Constantinidis and N. Papadopoulos and Yvette F. Tach{\'e} and George J Minopoulos and Dimitri E. Grigoriadis},
  journal={Journal of cellular physiology},
  year={2006},
  volume={209 3},
  pages={
          905-11
        }
}
Corticotropin-releasing factor agonists exert inhibitory effects in stomach functions possibly through peripheral routes. We have previously reported the expression of Urocortin (Ucn) I, an endogenous ligand of both CRF receptor types CRF(1) and CRF(2), in the human stomach. We examined CRF(1) and CRF(2) expression in the same tissue. Using RT-PCR, CRF(2) but not CRF(1) transcripts were detected in RNA extracts from normal human stomach. In addition, immunohistochemical analysis revealed… CONTINUE READING

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