Corticotropin-releasing factor (CRF) produces analgesia in humans and rats.

  title={Corticotropin-releasing factor (CRF) produces analgesia in humans and rats.},
  author={Kenneth M Hargreaves and Gregory P Mueller and Ronald Dubner and David S Goldstein and R. Dionne},
  journal={Brain research},
  volume={422 1},
The analgesic activity of corticotropin releasing factor (CRF) was determined in a clinical model and in the rat hot plate test. Patients administered CRF reported significantly less postoperative pain than patients pretreated with placebo. In rats, injection of CRF resulted in a significant analgesia which was comparable in both intensity and duration to a 300 times greater molar dose of morphine. These findings suggest that endogenous CRF may play a physiologic role in modulating pain when… CONTINUE READING