Corticotropin releasing factor (CRF) modulates fear-induced alterations in sleep in mice

@article{Yang2009CorticotropinRF,
  title={Corticotropin releasing factor (CRF) modulates fear-induced alterations in sleep in mice},
  author={Linghui Yang and Xiangdong Tang and Laurie L. Wellman and Xianling Liu and Larry D. Sanford},
  journal={Brain Research},
  year={2009},
  volume={1276},
  pages={112-122}
}
Contextual fear significantly reduces rapid eye movement sleep (REM) during post-exposure sleep in mice and rats. Corticotropin releasing factor (CRF) plays a major role in CNS responses to stressors. We examined the influence of CRF and astressin (AST), a non-specific CRF antagonist, on sleep after contextual fear in BALB/c mice. Male mice were implanted with transmitters for recording sleep via telemetry and with a guide cannula aimed into the lateral ventricle. Recordings for vehicle and… CONTINUE READING

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