Corticotropin increases protein tyrosine phosphatase activity by a cAMP-dependent mechanism in rat adrenal gland.

@article{Paz1999CorticotropinIP,
  title={Corticotropin increases protein tyrosine phosphatase activity by a cAMP-dependent mechanism in rat adrenal gland.},
  author={Cristina Paz and Fabiana Cornejo Maciel and Carmen M{\'e}ndez and Ernesto Jorge Podest{\'a}},
  journal={European journal of biochemistry},
  year={1999},
  volume={265 3},
  pages={911-8}
}
Corticotropin signal transduction pathway involves serine/threonine protein phosphorylation. Recent reports suggest that protein tyrosine dephosphorylation may also be an integral component of that pathway. The present study was performed to investigate the role played by protein tyrosine phosphatases (PTPs) on acute response to corticotropin and the hypothetical regulation of PTPs by this hormone. We have used two powerful cell permeant PTP inhibitors, phenylarsine oxide (PAO) and pervanadate… CONTINUE READING