Corticotropin and cortisol secretion after central 5-hydroxytryptamine-1A (5-HT1A) receptor activation: effects of 5-HT receptor and beta-adrenoceptor antagonists.

@article{Lesch1990CorticotropinAC,
  title={Corticotropin and cortisol secretion after central 5-hydroxytryptamine-1A (5-HT1A) receptor activation: effects of 5-HT receptor and beta-adrenoceptor antagonists.},
  author={Klaus-Peter Lesch and K. S{\"o}hnle and B. Poten and G{\"u}nter Sch{\"o}llnhammer and Rainer Rupprecht and Heinrich Maria Schulte},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1990},
  volume={70 3},
  pages={670-4}
}
To explore the involvement of 5-hydroxytryptamine-1A (5-HT1A) receptors in hypothalamic-pituitary-adrenal (HPA) axis regulation, various doses of ipsapirone (IPS), a centrally acting pyrimidinylpiperazine with considerable affinity and selectivity for 5-HT1A recognition sites, were administered to normal subjects. IPS dose-dependently increased plasma ACTH concentrations from -78 +/- 63 to 614 +/- 250 pmol.min/L (P less than 0.01) and plasma cortisol concentrations from -10.8 +/- 2.9 x 10(3) to… CONTINUE READING

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