Corticotropin‐releasing hormone binding to the syncytiotrophoblast membranes

@article{Saeed2001CorticotropinreleasingHB,
  title={Corticotropin‐releasing hormone binding to the syncytiotrophoblast membranes},
  author={B O Saeed and M. W. Thompson Fawcett and C. H. Self},
  journal={European Journal of Clinical Investigation},
  year={2001},
  volume={31}
}
The human placenta secretes large amounts of corticotropin‐releasing hormone (CRH) which was thought to exert a paracrine action in the placenta. We have recently characterized high‐affinity binding sites for CRH in the human placenta. However, our studies utilized whole placental membranes, which did not identify the site of binding of CRH in the plasma membrane. 

Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)

A positive feed-forward role exists for CRH in trophoblast cell differentiation, which may underlie the exponential rise in CRH observed as gestation advances.

Human fetal and maternal corticotrophin releasing hormone responses to acute stress

Acute fetal stress, caused by IHV needling of the fetal abdomen, resulted in hypothalamic-pituitary-adrenal axis activation, as shown by a rise in fetal cortisol and corticotrophin, which suggests that fetal plasma CRH is not derived from the hypophyseal-portal circulation, but from another source, presumably the placenta.

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Placental binding sites for CRH with properties similar to CRH receptors described in a number of human and animal tissues and with a molecular weight similar to that of the brain CRH receptor are identified and may be involved in the regulation of the placental CRH/ACTH-beta-endorphin axis during pregnancy and parturition.

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