Corticotropin‐releasing hormone binding to the syncytiotrophoblast membranes

  title={Corticotropin‐releasing hormone binding to the syncytiotrophoblast membranes},
  author={B O Saeed and M. W. Thompson Fawcett and C. H. Self},
  journal={European Journal of Clinical Investigation},
The human placenta secretes large amounts of corticotropin‐releasing hormone (CRH) which was thought to exert a paracrine action in the placenta. We have recently characterized high‐affinity binding sites for CRH in the human placenta. However, our studies utilized whole placental membranes, which did not identify the site of binding of CRH in the plasma membrane. 

Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)

A positive feed-forward role exists for CRH in trophoblast cell differentiation, which may underlie the exponential rise in CRH observed as gestation advances.

Human fetal and maternal corticotrophin releasing hormone responses to acute stress

Acute fetal stress, caused by IHV needling of the fetal abdomen, resulted in hypothalamic-pituitary-adrenal axis activation, as shown by a rise in fetal cortisol and corticotrophin, which suggests that fetal plasma CRH is not derived from the hypophyseal-portal circulation, but from another source, presumably the placenta.



Characterization of corticotropin-releasing hormone binding sites in the human placenta.

Placental binding sites for CRH with properties similar to CRH receptors described in a number of human and animal tissues and with a molecular weight similar to that of the brain CRH receptor are identified and may be involved in the regulation of the placental CRH/ACTH-beta-endorphin axis during pregnancy and parturition.

The corticotropin releasing hormone gene is expressed in human placenta.

Corticotropin-releasing factor-like activity in human placental extracts.

In cultures of rat anterior pituitary cells, the placental CRF-like material shows bioactivity similar to that of the partially purified rat hypothalamic CRF and synthetic ovine C R F on the release of adrenocorticotropin and (β-endorphin).

The identification of a human myometrial corticotropin-releasing hormone receptor that increases in affinity during pregnancy.

This work searched for specific CRH-binding sites in myometrial tissue obtained at biopsy from pregnant (cesarian section) and nonpregnant (hysterectomy) patients and found a single, specific, homogenous, high affinity population of CRH receptors in both tissues.

Parathyroid hormone receptor in human placental syncytiotrophoblast brush border and basal plasma membranes.

PTH influences, in vitro, phosphate transport through the placenta brush border membranes (BBM) and increases cAMP accumulation in placental tissue and it is probable that the binding of the hormone to this membrane activates another system of messengers.

Corticotropin-releasing hormone and oxytocin stimulate the release of placental proopiomelanocortin peptides.

It is found that human placenta releases IR-CRH and PomC-derived peptides in vitro; this phenomenon seems to be independent of glucocorticoid control; placental CRH may have a paracrine effect on placental POMC peptide release in addition to its possible action on maternal pituitary hormone release.

Evidence for local stimulation of ACTH secretion by corticotropin-releasing factor in human placenta

Using a monolayer primary culture of human placental cells, it is found that CRF stimulates secretion of peptides containing the ACTH sequence in the placenta in a dose-dependent manner, as it does in the pituitary.

Immunoreactive corticotropin-releasing hormone in human plasma during pregnancy, labor, and delivery.

We previously reported that immunoreactive corticotropin-releasing hormone (CRH) is present in human placenta and third trimester maternal plasma, and that such material is very similar to rat CRH