Corticotropic axis drive of overnight cortisol secretion is suppressed in adolescents and young adults with type 1 diabetes mellitus.

@article{Sharma2014CorticotropicAD,
  title={Corticotropic axis drive of overnight cortisol secretion is suppressed in adolescents and young adults with type 1 diabetes mellitus.},
  author={Animesh N Sharma and Jean R Wigham and Johannes D. Veldhuis},
  journal={Pediatric diabetes},
  year={2014},
  volume={15 6},
  pages={444-52}
}
CONTEXT Type 1 diabetes mellitus (T1DM) is a pro-inflammatory stress state, which, with its attendant hyperglycemia, likely disrupts hypothalamo-pituitary-adrenal (HPA) control, further dysregulating glucose homeostasis. OBJECTIVE To test the hypothesis that endogenous adrenocorticotropic hormone (ACTH)-cortisol dose-responsive drive, estimated analytically, is significantly accentuated in adolescents and young adults with T1DM compared with healthy individuals. DESIGN, SETTING, PATIENTS… CONTINUE READING
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Diabetes impairs hypothalamopituitaryadrenal ( HPA ) responses to hypoglycemia , and insulin 450

  • S Chan, K Inouye, K Shum, SG Matthews, M Vranic
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