Corticotrophin-releasing hormone receptor type 1: generation and characterization of polyclonal antipeptide antibodies and their localization in pituitary cells and cortical neurones in vitro.

@article{Castro1996CorticotrophinreleasingHR,
  title={Corticotrophin-releasing hormone receptor type 1: generation and characterization of polyclonal antipeptide antibodies and their localization in pituitary cells and cortical neurones in vitro.},
  author={Maria G Castro and Edward J. Morrison and Marcelo Javier Perone and Oscar A. Brown and Ciara A. Murray and Iman K. Ahmed and Anthony V Perkins and G. Nicholas Europe-Finner and Pedro R Lowenstein and Elizabeth A. Linton},
  journal={Journal of neuroendocrinology},
  year={1996},
  volume={8 7},
  pages={
          521-31
        }
}
Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide which plays a major role in regulating the endocrine response to stress. CRH acts by first binding to specific receptors on the plasma membrane of target cells. A CRH receptor from a human corticotroph adenoma and rat brain has recently been cloned (CRH-R1). In this paper, we have chosen three different peptide sequences within the CRH-R1 molecule which bear no similarity to other members of this receptor subfamily (or… CONTINUE READING

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