Corticotrophin-releasing factor and arginine vasopressin in the hypothalamo-hypophyseal portal blood of rats following high-dose glucocorticoid treatment and withdrawal.

@article{Eckland1991CorticotrophinreleasingFA,
  title={Corticotrophin-releasing factor and arginine vasopressin in the hypothalamo-hypophyseal portal blood of rats following high-dose glucocorticoid treatment and withdrawal.},
  author={D. J. A. Eckland and Michael S. Harbuz and David S. Jessop and Stafford L. Lightman},
  journal={Brain research},
  year={1991},
  volume={568 1-2},
  pages={311-3}
}
Hypothalamo-hypophyseal portal blood was obtained from rats treated with chronic, high-dose prednisolone in the drinking water and after subsequent withdrawal of the steroid for up to 7 days. Corticotrophin-releasing factor (CRF) immunoreactivity in portal blood was reduced by treatment with prednisolone but not completely abolished. There was a rapid… CONTINUE READING