Corticostriatal circuitry in regulating diseases characterized by intrusive thinking

@inproceedings{Kalivas2016CorticostriatalCI,
  title={Corticostriatal circuitry in regulating diseases characterized by intrusive thinking},
  author={Benjamin C. Kalivas and Peter W. Kalivas},
  booktitle={Dialogues in clinical neuroscience},
  year={2016}
}
Intrusive thinking triggers clinical symptoms in many neuropsychiatric disorders. Using drug addiction as an exemplar disorder sustained in part by intrusive thinking, we explore studies demonstrating that impairments in corticostriatal circuitry strongly contribute to intrusive thinking. Neuroimaging studies have long implicated this projection in cue-induced craving to use drugs, and preclinical models show that marked changes are produced at corticostriatal synapses in the nucleus accumbens… CONTINUE READING

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