Corticostriatal Afferents Modulate Responsiveness to Psychostimulant Drugs and Drug-Associated Stimuli

@article{Kerstetter2016CorticostriatalAM,
  title={Corticostriatal Afferents Modulate Responsiveness to Psychostimulant Drugs and Drug-Associated Stimuli},
  author={Kerry A. Kerstetter and Amanda M. Wunsch and Kanichi G Nakata and Elizabeth A Donckels and John F. Neumaier and Susan M Ferguson},
  journal={Neuropsychopharmacology},
  year={2016},
  volume={41},
  pages={1128-1137}
}
The medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) are both integral components of the corticobasal ganglia–thalamic circuitry that regulates addiction-related behaviors. However, the role of afferent inputs from mPFC to NAc in these behaviors is unclear. To address this, we used a Cre-recombinase-dependent viral vector approach to express Gi/o-coupled DREADDs (designer receptors exclusively activated by designer drugs) selectively in mPFC neurons projecting to the NAc and examined… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 11 times over the past 90 days. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Similar Papers

Loading similar papers…