Corticosterone-responsive and -unresponsive metabolic characteristics of adrenalectomized rats.

@article{Hamelink1994CorticosteroneresponsiveA,
  title={Corticosterone-responsive and -unresponsive metabolic characteristics of adrenalectomized rats.},
  author={Carol Hamelink and Paul Currie and Jeffrey W. Chambers and Thomas W. Castonguay and Donald V. Coscina},
  journal={The American journal of physiology},
  year={1994},
  volume={267 3 Pt 2},
  pages={
          R799-804
        }
}
Glucocorticoids are important in influencing substrate flux through the metabolic pathways. This study was designed to answer the question "Does adrenalectomy (ADX) cause a shift toward fat metabolism as measured by a decrease in respiratory quotient (RQ)?" Male Sprague-Dawley rats were divided into four groups, ADX, ADX + 20% corticosterone (Cort) (ADX-20%), ADX + 40% Cort (ADX-40%), or sham-operated controls (Sham). ADX-20% received 50 mg and ADX-40% 100 mg Cort dissolved in 250-mg… CONTINUE READING
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