Corticosterone exacerbates cyanide-induced cell death in hippocampal cultures: role of astrocytes.

@article{Chou1998CorticosteroneEC,
  title={Corticosterone exacerbates cyanide-induced cell death in hippocampal cultures: role of astrocytes.},
  author={Yueh-Ching Chou},
  journal={Neurochemistry international},
  year={1998},
  volume={32 3},
  pages={219-26}
}
Previous study demonstrated that, in hippocampal neuron/glia mixed cultures, glucocorticoids (GCs) enhanced extracellular overflow of [3H]D-aspartate [3H]D-Asp) by decreasing its uptake, thereby aggravating cell death during cyanide-induced ischemia. Since neuronal and glial cells respond to ischemic insult and GC differently, this study further evaluated the relative significance of these cells in GC endangering ischemic cell death. Using D-[2,3-3H]aspartic acid ([3H]D-Asp) as a tracer, it was… CONTINUE READING