Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis

  title={Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis},
  author={Y. Izumi and Kazuko A. O’Dell and C. Zorumski},
  journal={Frontiers in Cellular Neuroscience},
  • Y. Izumi, Kazuko A. O’Dell, C. Zorumski
  • Published 2015
  • Chemistry, Medicine
  • Frontiers in Cellular Neuroscience
  • Corticosterone is known to accumulate in brain after various stressors including alcohol intoxication. Just as severe alcohol intoxication is typically required to impair memory formation only high concentrations of ethanol (60 mM) acutely inhibit long-term potentiation (LTP), a cellular memory mechanism, in naïve hippocampal slices. This LTP inhibition involves synthesis of neurosteroids, including allopregnanolone, and appears to involve a form of cellular stress. In the CA1 region of rat… CONTINUE READING
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