• DOI:10.3389/fncel.2015.00254
Corpus ID: 11165585

Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis

@article{Izumi2015CorticosteroneET,
  title={Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis},
  author={Y. Izumi and Kazuko A. O’Dell and C. Zorumski},
  journal={Frontiers in Cellular Neuroscience},
  year={2015},
  volume={9}
}

Y. Izumi, Kazuko A. O’Dell, C. Zorumski

Published 2015

Chemistry, Medicine

Frontiers in Cellular Neuroscience

Corticosterone is known to accumulate in brain after various stressors including alcohol intoxication. Just as severe alcohol intoxication is typically required to impair memory formation only high concentrations of ethanol (60 mM) acutely inhibit long-term potentiation (LTP), a cellular memory mechanism, in naïve hippocampal slices. This LTP inhibition involves synthesis of neurosteroids, including allopregnanolone, and appears to involve a form of cellular stress. In the CA1 region of rat… CONTINUE READING

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