Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking.

@article{Graf2013CorticosteroneAI,
  title={Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking.},
  author={Evan N Graf and Robert A Wheeler and David A Baker and Amanda L. Ebben and Jonathan E. Hill and Jayme R. McReynolds and Mykel A. Robble and Oliver Vranjkovic and Daniel S. Wheeler and John R. Mantsch and Paul J Gasser},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 29},
  pages={11800-10}
}
Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems are poorly understood. Studies suggest that stress may "set the stage" for relapse by increasing the sensitivity of brain reward circuits to drug-associated stimuli. We examined the effects of stress and corticosterone on behavioral and neurochemical responses of rats to a cocaine prime after cocaine self-administration and extinction… CONTINUE READING