Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3

@article{McReynolds2017CorticosteronePO,
  title={Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3},
  author={Jayme R. McReynolds and Analisa Taylor and Oliver Vranjkovic and Terra Ambrosius and Olivia Derricks and Brittany Nino and Beliz Kurtoglu and Robert A Wheeler and David K. Baker and Paul J Gasser and John R. Mantsch},
  journal={Neuropsychopharmacology},
  year={2017},
  volume={42},
  pages={757-765}
}
The mechanisms by which stressful life events increase the risk of relapse in recovering cocaine addicts are not well understood. We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking following self-administration in rats and that this potentiation appears to involve corticosterone-induced blockade of dopamine clearance via the organic cation transporter 3 (OCT3). In the present study, we use a conditioned place preference… CONTINUE READING

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