Corticosterone Modulates Auditory Gating in Mouse

  title={Corticosterone Modulates Auditory Gating in Mouse},
  author={Christina R. Maxwell and Richard S. Ehrlichman and Yuling Liang and David R. Gettes and Dwight L. Evans and Stephen J. Kanes and Ted Abel and Jonathan Karp and Steven J. Siegel},
Previous studies suggest that circulating glucocorticoids may influence the encoding and processing of sensory stimuli. The current study investigated this hypothesis by measuring the generation (amplitude), gating (recovery cycle), and sensitivity (intensity function) of auditory evoked responses in C57BL/6 mice treated with chronic corticosterone (0, 1, 5, 15, or 30 mg/kg/day for 14 days). We found that low-dose corticosterone (5 but not 1 mg/kg/day) enhanced the amplitude and improved gating… CONTINUE READING