Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory state.

@article{Broering2011CorticosteroidsST,
  title={Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory state.},
  author={Ruth Broering and Mario Montag and Min Jiang and Mengji Lu and Jan-Peter Sowa and Kathrin Kleinehr and Guido G H Gerken and Joerg Friedrich Schlaak},
  journal={International immunology},
  year={2011},
  volume={23 9},
  pages={537-44}
}
OBJECTIVE Only little is known about the mechanisms of action of corticosteroids in the treatment of inflammatory liver diseases. As there is increasing evidence that stimulation of the innate immune system plays an important pathogenetic role in these conditions, we hypothesized that steroids may interfere with the activation of the Toll-like receptor (TLR) system of the liver. METHODS To test this hypothesis, murine non-parenchymal liver cells (Kupffer cells, liver sinusoidal endothelial… CONTINUE READING
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