Corticosteroids in relation to fear, anxiety and psychopathology

@article{Korte2001CorticosteroidsIR,
  title={Corticosteroids in relation to fear, anxiety and psychopathology},
  author={Sijmen Mechiel Korte},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2001},
  volume={25},
  pages={117-142}
}
  • S. Korte
  • Published 1 March 2001
  • Psychology, Biology
  • Neuroscience & Biobehavioral Reviews

Genetic modification of corticosteroid receptor signalling: Novel insights into pathophysiology and treatment strategies of human affective disorders

There is evidence indicating that cortisol-lowering or corticosteroid receptor antagonist treatments may be of clinical benefit in selected individuals with major depression, and a more detailed knowledge of the GR signalling pathways opens up the possibility to specifically target GR function.

The biology of fear- and anxiety-related behaviors

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    Dialogues in clinical neuroscience
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Contextual control over expression of fear is affected by cortisol

The results indicated that people rapidly acquire differential contextual modulation of the expression of fear, as measured by fear potentiated startle (FPS) and skin conductance responses (SCR) and cortisol impaired differential conditioning in men.

The neurobiology and control of anxious states

  • M. Millan
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A neuroendocrine mechanism for sustaining fear

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This work discusses how stress and the endocrine mediators of the stress response influence the morphological and electrophysiological properties of neurons in brain areas that are crucial for fear-conditioning processes, including the amygdala, hippocampus, and prefrontal cortex.

Mineralocorticoid receptors control emotional arousal and fear extinction

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It is concluded that under stress, deletion of forebrain MR function increases emotional arousal resulting in increased anxiety-related responses and fear memories appear to be enhanced due to stronger consolidation and resistance to extinction probably caused by the higher corticosterone concentrations acting via GR in the absence of fore brain MR.
...

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