Corticosteroids in relation to fear, anxiety and psychopathology

  title={Corticosteroids in relation to fear, anxiety and psychopathology},
  author={Sijmen Mechiel Korte},
  journal={Neuroscience \& Biobehavioral Reviews},
  • S. Korte
  • Published 1 March 2001
  • Psychology, Biology
  • Neuroscience & Biobehavioral Reviews

Genetic modification of corticosteroid receptor signalling: Novel insights into pathophysiology and treatment strategies of human affective disorders

There is evidence indicating that cortisol-lowering or corticosteroid receptor antagonist treatments may be of clinical benefit in selected individuals with major depression, and a more detailed knowledge of the GR signalling pathways opens up the possibility to specifically target GR function.

The biology of fear- and anxiety-related behaviors

  • T. Steimer
  • Psychology, Biology
    Dialogues in clinical neuroscience
  • 2002
The biology of fear and anxiety will be examined from systemic (brain-behavior relationships, neuronal circuitry, and functional neuroanatomy) and cellular/molecular (neurotransmitters, hormones, and other biochemical factors) points of view, with particular reference to animal models.

Contextual control over expression of fear is affected by cortisol

The results indicated that people rapidly acquire differential contextual modulation of the expression of fear, as measured by fear potentiated startle (FPS) and skin conductance responses (SCR) and cortisol impaired differential conditioning in men.

The neurobiology and control of anxious states

  • M. Millan
  • Biology, Psychology
    Progress in Neurobiology
  • 2003

A neuroendocrine mechanism for sustaining fear

The influence of stress hormones on fear circuitry.

This work discusses how stress and the endocrine mediators of the stress response influence the morphological and electrophysiological properties of neurons in brain areas that are crucial for fear-conditioning processes, including the amygdala, hippocampus, and prefrontal cortex.

Mineralocorticoid receptors control emotional arousal and fear extinction

  • Biology, Psychology
  • 2009
It is concluded that under stress, deletion of forebrain MR function increases emotional arousal resulting in increased anxiety-related responses and fear memories appear to be enhanced due to stronger consolidation and resistance to extinction probably caused by the higher corticosterone concentrations acting via GR in the absence of fore brain MR.



Corticosterone Potentiation of Conditioned Fear in Rats a

Whether CORT would potentiate fear responses (freezing) conditioned to acoustic stimuli and a two-way analysis of variance (ANOVA) with one grouping variable (hormone) is investigated.

The role of corticotropin-releasing factor in depression and anxiety disorders.

The hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics, probably through its effects on central noradrenergic systems, is supported.

The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies.

Clinical studies reveal that drug-free depressed patients show hyperactivity of the hypothalamo-pituitary-adrenal axis and a blunted release of ACTH in response to CRF, concordant with hypersecretion of CRF from hypothalamic and extrahypothalamic CRF neurons in depression.

The role of the central amygdala in stress and adaption.

An attempt is made to provide an integrated model of CEA functioning in relation to stress and adaptation, and it is proposed that the CEA is consistently involved in the organisation of processes of passive coping, reflected in immobile behaviour and parasympathetic activity.

The Role of CRF in Behavioral Aspects of Stress

These actions of CRF in coordinating coping responses to stress at several bodily levels are consistent with a role for CRF similar to the dual role of other hypothalamic releasing factors in integrating hormonal and neural mechanisms by acting both as secretagogues for anterior pituitary hormones and as extrapituitary peptide neurotransmitters.

The Role and Mechanisms of Action of Glucocorticoid Involvement in Memory Storage

  • C. Sandi
  • Biology, Psychology
    Neural plasticity
  • 1998
Certain components of the physiological response to stress elicited by learning situations are proposed to form an integral aspect of the neurobiological mechanism underlying memory formation.

Brain corticosteroid receptor balance in health and disease.

The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.

Anti-Stress Action of a Corticotropin-Releasing Factor Antagonist on Behavioral Reactivity to Stressors of Varying Type and Intensity

Results suggest that antagonism of activated brain CRF systems attenuates the behavioral response to stress regardless of the type or intensity of the stressor as measured by ACTH secretion.