Corticosteroids in relation to fear, anxiety and psychopathology

@article{Korte2001CorticosteroidsIR,
  title={Corticosteroids in relation to fear, anxiety and psychopathology},
  author={Sijmen Mechiel Korte},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2001},
  volume={25},
  pages={117-142}
}
  • S. Korte
  • Published 1 March 2001
  • Psychology, Biology
  • Neuroscience & Biobehavioral Reviews
View on Elsevier
doi.org
589 Citations
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Methods Citations
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Results Citations
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References

SHOWING 1-10 OF 285 REFERENCES

Corticosterone Potentiation of Conditioned Fear in Rats a

Whether CORT would potentiate fear responses (freezing) conditioned to acoustic stimuli and a two-way analysis of variance (ANOVA) with one grouping variable (hormone) is investigated.

The role of corticotropin-releasing factor in depression and anxiety disorders.

The hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics, probably through its effects on central noradrenergic systems, is supported.

Hippocampal Mineralocorticoid, but Not Glucocorticoid, Receptors Modulate Anxiety-Like Behavior in Rats

The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies.

Clinical studies reveal that drug-free depressed patients show hyperactivity of the hypothalamo-pituitary-adrenal axis and a blunted release of ACTH in response to CRF, concordant with hypersecretion of CRF from hypothalamic and extrahypothalamic CRF neurons in depression.

The role of the central amygdala in stress and adaption.

An attempt is made to provide an integrated model of CEA functioning in relation to stress and adaptation, and it is proposed that the CEA is consistently involved in the organisation of processes of passive coping, reflected in immobile behaviour and parasympathetic activity.

Stress and cognition: are corticosteroids good or bad guys?

The Role of CRF in Behavioral Aspects of Stress

These actions of CRF in coordinating coping responses to stress at several bodily levels are consistent with a role for CRF similar to the dual role of other hypothalamic releasing factors in integrating hormonal and neural mechanisms by acting both as secretagogues for anterior pituitary hormones and as extrapituitary peptide neurotransmitters.

The Role and Mechanisms of Action of Glucocorticoid Involvement in Memory Storage

  • C. Sandi
  • Biology, Psychology
    Neural plasticity
  • 1998
Certain components of the physiological response to stress elicited by learning situations are proposed to form an integral aspect of the neurobiological mechanism underlying memory formation.

Brain corticosteroid receptor balance in health and disease.

The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.

Anti-Stress Action of a Corticotropin-Releasing Factor Antagonist on Behavioral Reactivity to Stressors of Varying Type and Intensity

Results suggest that antagonism of activated brain CRF systems attenuates the behavioral response to stress regardless of the type or intensity of the stressor as measured by ACTH secretion.
...