Corticosteroids and bone health in people with asthma: A systematic review and meta-analysis.

  title={Corticosteroids and bone health in people with asthma: A systematic review and meta-analysis.},
  author={Christos V. Chalitsios and Dominick Edward Shaw and Tricia M. McKeever},
  journal={Respiratory medicine},
Fracture risk associated with glucocorticoid-induced osteoporosis in Japan
The use of glucocorticoids was associated with an increase in the incidence of osteoporotic fractures and tended to be higher in subgroups of patients with rheumatoid arthritis, asthma, COPD and in those aged < 65 years.


Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis
ICS use for ≥12 months in adults or children with asthma was not significantly associated with harmful effects on fractures or bone mineral density.
Influence of Obesity on Bone Mineral Density in Postmenopausal Asthma Patients Undergoing Treatment with Inhaled Corticosteroids
There is a slight positive protective effect of high BMI against osteoporosis in asthma patients, but this effect is overcome by time and menopause status, therefore, the protective effects of obesity against osteofiltration in asthma Patients seems to not be significant.
Cross sectional investigation of the effects of inhaled corticosteroids on bone density and bone metabolism in patients with asthma.
Findings are in keeping with an effect of inhaled steroid therapy in reducing bone density in the spine in women and provide an estimate of the magnitude of this effect.
Inhaled steroids do not decrease bone mineral density but increase risk of fractures: data from the GIUMO Study Group.
  • M. Sosa, P. Saavedra, M. Díaz-Curiel
  • Medicine, Biology
    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
  • 2006
Bone mineral density in perimenopausal women with asthma: a population-based cross-sectional study.
Although BMDs were not significantly decreased in the asthmatics who had used inhaled corticosteroids, the duration of use correlated negatively with spinal BMD and was also associated with spinalBMD in multiple regression analysis.
Impact of long-term inhaled corticosteroid therapy on bone mineral density: results of a meta-analysis.
Impact of treatment with inhaled corticosteroids on bone mineral density of patients with asthma: related with age
This study indicates that BMD reduction in ICS user with asthma is dependent on age and appears that younger patients are at greater risk of BMD loss, particularly in patients <50 years.
Bone mineral density in asthmatic patients treated with inhaled corticosteroids: a case-control study.
Bone mineral density (BMD) was measured in 48 asthmatic adults treated with inhaled steroids and in 48 gender and age-matched healthy subjects at baseline and at 2 yrs, and no differences were found in bone loss when pre- and postmenopausal women were compared with their healthy control counterparts.
Effects of inhaled corticosteroid and short courses of oral corticosteroids on bone mineral density in asthmatic patients : a 4-year longitudinal study.
ICS therapy per se does not affect BMD, whereas frequent SC-OCS may do so, and as a whole, lumbar BMD was unchanged during the course of the study, whereas the Z score increased significantly.