Corticosteroids and bone health in people with asthma: A systematic review and meta-analysis.

  title={Corticosteroids and bone health in people with asthma: A systematic review and meta-analysis.},
  author={Christos V. Chalitsios and Dominick E. Shaw and Tricia M. McKeever},
  journal={Respiratory medicine},
BACKGROUND Understanding the potential deleterious effects of corticosteroids on bone health in people with asthma is important when making treatment decisions. There is a need for clearer evidence to better quantify the risk and effect size. METHODS Databases were systematically searched to identify studies reporting on bone mineral density (BMD) measurement and risk of osteoporosis or fracture, comparing people with asthma exposed to inhaled (ICS) or oral (OCS) corticosteroids, with… 


Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis
ICS use for ≥12 months in adults or children with asthma was not significantly associated with harmful effects on fractures or bone mineral density.
Influence of Obesity on Bone Mineral Density in Postmenopausal Asthma Patients Undergoing Treatment with Inhaled Corticosteroids
There is a slight positive protective effect of high BMI against osteoporosis in asthma patients, but this effect is overcome by time and menopause status, therefore, the protective effects of obesity against osteofiltration in asthma Patients seems to not be significant.
Cross sectional investigation of the effects of inhaled corticosteroids on bone density and bone metabolism in patients with asthma.
Findings are in keeping with an effect of inhaled steroid therapy in reducing bone density in the spine in women and provide an estimate of the magnitude of this effect.
Inhaled steroids do not decrease bone mineral density but increase risk of fractures: data from the GIUMO Study Group.
  • M. Sosa, P. Saavedra, +13 authors M. Díaz-Curiel
  • Medicine
    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
  • 2006
Inhaled steroids do not appear to decrease BMD, but are associated with an increased risk of fracture in women, according to a cross-sectional study performed on women suffering from bronchial asthma treated with inhaled steroids.
Bone mineral density in perimenopausal women with asthma: a population-based cross-sectional study.
Although BMDs were not significantly decreased in the asthmatics who had used inhaled corticosteroids, the duration of use correlated negatively with spinal BMD and was also associated with spinalBMD in multiple regression analysis.
Impact of long-term inhaled corticosteroid therapy on bone mineral density: results of a meta-analysis.
Long-term use of ICSs in patients with asthma or COPD was not associated with significant changes in BMD and annual changes from baseline in lumbar, femoral neck, and major trochanter BMD were not statistically significant.
Impact of treatment with inhaled corticosteroids on bone mineral density of patients with asthma: related with age
This study indicates that BMD reduction in ICS user with asthma is dependent on age and appears that younger patients are at greater risk of BMD loss, particularly in patients <50 years.
Bone mineral density in asthmatic patients treated with inhaled corticosteroids: a case-control study.
Bone mineral density (BMD) was measured in 48 asthmatic adults treated with inhaled steroids and in 48 gender and age-matched healthy subjects at baseline and at 2 yrs, and no differences were found in bone loss when pre- and postmenopausal women were compared with their healthy control counterparts.
Effects of inhaled corticosteroid and short courses of oral corticosteroids on bone mineral density in asthmatic patients : a 4-year longitudinal study.
ICS therapy per se does not affect BMD, whereas frequent SC-OCS may do so, and as a whole, lumbar BMD was unchanged during the course of the study, whereas the Z score increased significantly.
Inhaled corticosteroid use and bone-mineral density in patients with asthma
There was a negative association between cumulative dose of inhaled corticosteroid and bone-mineral density at the lumbar spine, femoral neck, Ward's triangle, and trochanter, both before and after adjustment for the effects of age and sex.