Corticosteroids and Ulcers: Is There an Association?

@article{Pecora1996CorticosteroidsAU,
  title={Corticosteroids and Ulcers: Is There an Association?},
  author={P G Pecora and Barbara Kaplan},
  journal={Annals of Pharmacotherapy},
  year={1996},
  volume={30},
  pages={870 - 872}
}
The literature presented supports a small but highly probable association between corticosteroids and ulcers. The following characteristics appear to be exhibited by patients who are at high risk for developing corticosteroid-induced ulcers: corticosteroids coadministered with NSAIDs, a total dosage greater than 1000 mg of prednisone equivalent, a duration of therapy longer than 30 days, and a history of PUD. Further prospective research examining the association of corticosteroids and PUD in… 
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Side Effects of Corticosteroid Therapy
  • A. Buchman
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TLDR
Short-term corticosteroid use is associated with generally mild side effects, including cutaneous effects, electrolyte abnormalities, hypertension, hyperglycemia, pancreatitis, hematologic, immunologic, and neuropsychologic effects, although occasionally, clinically significant side effects may occur.
SUMMARY Optimum management of glucocorticoid-treated
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Regular ophthalmic screening for cataracts and glaucoma is warranted, and patients at high- risk of gastric ulceration (especially patients simultaneously taking nonsteroidal anti-inflammatory drugs) should receive proton-pump inhibitors, andphylaxis against opportunistic infections is appropriate for high-risk populations, such as organ-transplant recipients.
Optimum management of glucocorticoid-treated patients
TLDR
Regular ophthalmic screening for cataracts and glaucoma is warranted, and patients at high-risk of gastric ulceration (especially patients simultaneously taking nonsteroidal anti-inflammatory drugs) should receive proton-pump inhibitors andphylaxis against opportunistic infections is appropriate for high- risk populations, such as organ-transplant recipients.
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Whether patients receiving CS therapy are evaluated and treated for osteoporosis risk, how management varied by steroid dose and diagnosis, and how many patients received gastro-protection are determined.
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More than 25% of all kidney recipients required upper endoscopy in their 'post-transplant life'; the prevalence of 'positive findings' and ulcer disease was higher than in the general population (P<0.0001); the most vulnerable period is the first 3 months.
High frequency of ulcers , not associated with Helicobacter pylori , in the stomach in the first year after kidney transplantation
Background. Although gastrointestinal (GI) symptoms are very frequent in organ transplant patients, there is a paucity of data about the endoscopic findings of kidney recipients. Methods. Two…
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Recommendations for peri-operative glucocorticoid treatment have become standard practice and there now appears to be an ingrained consensus that patients, currently or recently taking exogenous steroids, require additional large doses of steroids when subjected to surgery.
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Low dose corticosteroids appear to be adequate in the initial management of these adult patients with acute severe asthma, and higher doses do not appear to offer a therapeutic advantage.
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It was found that, despite some controversy in the use of corticosteroid treatment in the sports environment, little empirical evidence exists that could conclusively rule for or against its use.
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