Corticosteroid-responsive focal granulomatous herpes simplex type-1 encephalitis in adults

@article{Varatharaj2017CorticosteroidresponsiveFG,
  title={Corticosteroid-responsive focal granulomatous herpes simplex type-1 encephalitis in adults},
  author={Aravinthan Varatharaj and James A R Nicoll and Emanuela Pelosi and Ashwin Arnold Pinto},
  journal={Practical Neurology},
  year={2017},
  volume={17},
  pages={140 - 144}
}
We describe corticosteroid-responsive focal granulomatous encephalitis as a manifestation of herpes simplex virus (HSV) type 1 disease in the brain: something easily missed and easily treated. Two adult cases presented with cognitive symptoms progressing over weeks, despite aciclovir treatment. Brain imaging showed temporal lobe abnormalities, with gadolinium enhancement but no abnormal diffusion restriction. HSV-1 PCR analysis was negative in cerebrospinal fluid (CSF) but positive in brain… Expand
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