Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages.

@article{Goleva2008CorticosteroidresistantAI,
  title={Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages.},
  author={Elena Goleva and Pia J. Hauk and Clifton F. Hall and Andrew H. Liu and David W. H. Riches and Richard J. Martin and Donald Y. M. Leung},
  journal={The Journal of allergy and clinical immunology},
  year={2008},
  volume={122 3},
  pages={550-9.e3}
}
BACKGROUND The cause of corticosteroid-resistant (CR) asthma is unknown. OBJECTIVE We sought to perform gene microarray analyses by using bronchoalveolar lavage (BAL) cells from well-characterized subjects with CR asthma and subject with corticosteroid-sensitive (CS) asthma to elucidate the differential expression of genes that contribute to the development of corticosteroid resistance. METHODS The patients were characterized as having CR or CS asthma based on FEV(1) percent predicted… CONTINUE READING

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