Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience.

@article{Derijk2008CorticosteroidRP,
  title={Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience.},
  author={Roel H Derijk and E. Ron de Kloet},
  journal={European journal of pharmacology},
  year={2008},
  volume={583 2-3},
  pages={303-11}
}
Why some individuals thrive and others break down under similar adverse conditions, is a central question in the neuroendocrinology of stress related psychopathology. The brain mineralocorticoid (MR) and glucocorticoid receptors (GR) operate in balance to coordinate behavioural, autonomic and neuroendocrine response patterns involved in homeostasis and health. Genetic variants of both the MR and GR have been functionally characterized. The four GR-gene single nucleotide polymorphisms (SNPs… CONTINUE READING