Corticosteroid effect on granulopoiesis in mice after cyclophosphamide.

  title={Corticosteroid effect on granulopoiesis in mice after cyclophosphamide.},
  author={Rosemary A. Joyce and Paul A. Chervenick},
  journal={The Journal of clinical investigation},
  volume={60 2},
Corticosteroids cause an enhanced return of granulopoiesis as measured by in vitro growth of granulocytic progenitor cells (CFU-C) in mice treated with cyclophosphamide. After methylprednisolone and cyclophosphamide, a greater than threefold increase in marrow CFU-C was measured on day 4 compared to mice given cyclophosphamide alone (29,700+/-200 vs. 8,400+/-700/humerus). The accelerated return of marrow CFU-C was observed with cyclophosphamide in doses of 200 and 450 mg/kg and… CONTINUE READING


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