Corticosteroid-binding globulin mRNA levels in human uterine endometrium

@article{Misao1994CorticosteroidbindingGM,
  title={Corticosteroid-binding globulin mRNA levels in human uterine endometrium},
  author={Ryou Misao and Masashi Hori and Satoshi Ichigo and Jiro Fujimoto and Teruhiko Tamaya},
  journal={Steroids},
  year={1994},
  volume={59},
  pages={603-607}
}
Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. CBG has been previously shown to be synthesized in the liver, but recently it has been reported that immunoreactive CBG is localized in target tissues. In the present work, CBG mRNA was detected in normal… Expand
Expression of corticosteroid-binding globulin mRNA in human uterine endometrial cancers
TLDR
The results suggest that dedifferentiation of endometrial cancers induces a reduction in intracellular CBG synthesis, which is significantly higher in secretory phase endometrium than in early and late proliferative phaseendometrium. Expand
Sex hormone-binding globulin and corticosteroid-binding globulin mRNA levels in infertile women with luteal phase deficiency.
TLDR
Findings suggest that the synthesis of endometrial steroid-binding proteins in the out-of-phase endometrium is conserved, as that in the in-phaseendometrium, whereas the decreased progesterone level might up-regulate CBG expression with down-regulation of SHBG expression. Expand
Levels of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) messenger ribonucleic acid (mRNAs) in ovarian endometriosis.
TLDR
It is suggested that overexpression of intercellular SHBG in endometriotic tissues results in the formation of the estrogen-predominant milieu, since SHBG-bound estrogen is considered to be protected from the metabolism in liver and available in Endometrial cells, thereby assisting the development of the pelvic endometRIosis. Expand
Levels of sex hormone-binding globulin and corticosteroid-binding globulin mRNAs in corpus luteum of human subjects: correlation with serum steroid hormone levels.
TLDR
The findings suggest that the synthesis of luteal SHBG and CBG is complexly regulated by estrogen and progesterone, and that SHBGand CBG interact with estrogen andprogesterone, respectively, for lutenal steroidal activity. Expand
Levels of Corticosteroid-Binding Globulin mRNA in Human Ovarian Cancers
TLDR
The data suggest that human normal ovaries and ovarian cancers might synthesize CBG intracellularly, ovarian cancersmight conserve a progesterone-associated property via CBG, and the regulation of intracelluar CBG expression might be changed in some cancers. Expand
Differential Effects of Estrogen on Corticosteroid-Binding Globulin Forms Suggests Reduced Cleavage in Pregnancy
TLDR
Results were consistent with an estrogen-mediated increase in CBG synthesis in both hyperestrogenemic states but with reduced CBG cleavage in pregnancy relative to the COCP, perhaps due to pregnancy-induced CBG glycosylation. Expand
Corticosteroid-binding globulin, induced in testicular Leydig cells by perfluorooctanoic acid, promotes steroid hormone synthesis
TLDR
Serum CBG levels in all three PFOA groups also increased, accompanied by increased corticosterone in the 5 and 20  mg/kg/day groups and decreased adrenocorticotropic hormone in the 20 mg/ kg/day group, thereby serving as an endocrine disruptor. Expand
Effects of Sex Steroid Hormones on Corticosteroid-Binding Globulin Gene Expression in Human Endometrial Cancer Cell Line Ishikawa
TLDR
Findings suggest that the effects of high-dose progestins on cancer cells may be mediated via suppression of intracellular CBG. Expand
Intrauterine cortisol, aldosterone, and corticosteroid binding globulin-like activity during early porcine pregnancy and the estrous cycle.
TLDR
It is indicated that corticosteroids are present-primarily in the free form-within the porcine uterine lumen and could influence early porCine conceptus development. Expand
Corticosteroid-binding globulin: The clinical significance of altered levels and heritable mutations
TLDR
There are preliminary data of altered CBG levels in hypertension and in the metabolic syndrome; however, the nature of these associations is uncertain. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 38 REFERENCES
Role of corticosteroid-binding globulin in interaction of corticosterone with uterine and brain progesterone receptors
TLDR
It is shown that there are differences between progesterone receptors in brain and uterus, and possibly in the distribution of the serum progestersone-binding protein, corticosteroid-binding globulin (CBG), which may enter uterine but not brain cells. Expand
Biological Inactivation of Progesterone by Interaction with Corticosteroid-binding Globulin and with Albumin
Publisher Summary The binding affinity between progesterone and corticosteroid-binding globulin (CBG or transcortin), exceeds that of cortisol-CBG complex in man and guinea pig. In human pregnancy,Expand
Immunocytochemical localization of corticosteroid-binding globulin in rat tissues.
TLDR
Investigation of immunocytochemical localization of rat CBG found the presence of immunoreactive CBG in specific cells of some glucocorticoid-responsive tissues and not others raises interesting questions concerning the transport of glucOCorticoids and their mechanism of action. Expand
Effect of clomiphene citrate on corticosteroid-binding globulin and serum progesterone levels during ovulation induction.
TLDR
An alteration in serum binding protein levels appears to be secondary to a direct effect of Clomid on hepatic synthesis and may have significance in relation to progesterone binding and metabolism during ovulation induction with Clomids. Expand
Glucocorticoid and estrogen regulation of corticosteroid-binding globulin production by rat liver.
TLDR
The hormonal regulation of hepatic CBG production is examined and the possible clinical implications of the therapeutic use of glucocorticoids that bind to CBG, yet inhibitCBG production, are discussed. Expand
Synthesis and secretion of corticosteroid-binding globulin by rat liver. A source of heterogeneity of hepatic corticosteroid-binders.
TLDR
In conclusion, liver synthesizes and secretes type III sites, a finding previously suspected but never proved, and the presence oftype III sites in kidney remains to be explained. Expand
The serum transport of steroid hormones.
TLDR
This chapter discusses the serum transport of steroid hormones, where the steroid-receptor complex apparently moves into the nucleus where it modifies the chromatin transcriptional activity which results in altered levels of protein synthesis. Expand
Specific localization of plasma corticosteroid-binding globulin immunoreactivity in pituitary corticotrophs.
TLDR
The purpose of this study was to investigate the presence of corticosteroid-binding globulin (CBG) in guinea pig pituitary by immunohistochemical methods and found that "CBG-like" antigen was only found in the corticotrophs. Expand
Hormonal control of postnatal development of corticosteroid-binding globulin.
TLDR
The results suggest that the developmental rise in the binding capacity of CBG is independent of estradiol and estrone and instead is elicited by the rising concentrations of circulating thyroxine that normally occur in the early postnatal period. Expand
Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma.
TLDR
A model of steroid transport in human plasma is described, finding that normal men, normal women during both the follicular and luteal phases of the ovarian cycle, and women during the third trimester of a normal pregnancy are candidates for steroid transport. Expand
...
1
2
3
4
...