Corticosteroid alteration of active electrolyte transport in rat distal colon.

  title={Corticosteroid alteration of active electrolyte transport in rat distal colon.},
  author={Evan Foster and Thomas W. Zimmerman and John P. Hayslett and Henry Joseph Binder},
  journal={The American journal of physiology},
  volume={245 5 Pt 1},
To determine the effect of corticosteroids on active transport processes, unidirectional fluxes of 22Na, 36Cl, and 42K were measured under short-circuit conditions across isolated stripped distal colonic mucosa of the rat in control, secondary hyperaldosterone, and dexamethasone-treated animals. In controls net sodium and chloride fluxes (JNanet and JClnet) and short-circuit current (Isc) were 6.6 +/- 2.2, 7.6 +/- 1.6, and 1.3 +/- 0.2 mu eq X h-1 X cm-2, respectively. Although aldosterone… CONTINUE READING


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