Corticosteroid-Responsive Cryptogenic Chronic Hepatitis: Evidence for Seronegative Autoimmune Hepatitis

@article{Gassert2006CorticosteroidResponsiveCC,
  title={Corticosteroid-Responsive Cryptogenic Chronic Hepatitis: Evidence for Seronegative Autoimmune Hepatitis},
  author={Daniel J. Gassert and Heriberto Garcia and Katherine H. Tanaka and John F. Reinus},
  journal={Digestive Diseases and Sciences},
  year={2006},
  volume={52},
  pages={2433-2437}
}
Cryptogenic chronic hepatitis (CCH) is diagnosed in patients with persistently elevated aminotransferase levels of unknown etiology. The workup of CCH patients must include a liver biopsy in order to exclude the largely unrecognized diagnosis of seronegative autoimmune hepatitis (SAIH). Patients with SAIH have demographic, biochemical, and histologic features of autoimmune hepatitis (AIH) and may be treated effectively with corticosteroids. Recognition and treatment of SAIH are necessary to… CONTINUE READING