Corticosteroid Regulation of Synaptic Plasticity in the Hippocampus

  title={Corticosteroid Regulation of Synaptic Plasticity in the Hippocampus},
  author={Nicola Maggio and Menahem Segal},
Stress, via release of steroid hormones, has been shown to affect several cellular functions in the brain, including synaptic receptors and ion channels. As such, corticosteroids were reported to modulate plasticity, expressed as long-term changes in reactivity to afferent stimulation. The classical view of the effects of stress on synaptic plasticity and cognitive functions assumes an inverted U-shape curve, such that a low stress level facilitates and a high stress level (i.e., corticosterone… CONTINUE READING