Corticosteroid Plus Pentoxifylline Is Not Better than Corticosteroid Alone for Improving Survival in Severe Alcoholic Hepatitis (COPE Trial)

@article{Sidhu2012CorticosteroidPP,
  title={Corticosteroid Plus Pentoxifylline Is Not Better than Corticosteroid Alone for Improving Survival in Severe Alcoholic Hepatitis (COPE Trial)},
  author={Sandeep Singh Sidhu and Omesh Goyal and Preeti Singla and Dinesh K. Gupta and Ajit Sood and Rajoo Singh Chhina and Ravinder Kumar Soni},
  journal={Digestive Diseases and Sciences},
  year={2012},
  volume={57},
  pages={1664-1671}
}
Corticosteroids and pentoxifylline reduce short-term mortality in severe alcoholic hepatitis (SAH), but not to the extent desired. Combining both drugs may lead to better survival, but has not yet been studied. To compare the efficacy of corticosteroids plus pentoxifylline with that of corticosteroids alone in improving survival of SAH patients. Of the 111 patients screened, 70 patients with SAH (Maddrey discriminant function (MDF) ≥ 32) were enrolled. Patients with active infection, bleeding… CONTINUE READING

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Medical Management of Severe Alcoholic Hepatitis: Expert Review from the Clinical Practice Updates Committee of the AGA Institute.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association • 2017
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