Corticosteroid-Induced Adverse Psychiatric Effects

  title={Corticosteroid-Induced Adverse Psychiatric Effects},
  author={Scott B. Patten and C. Ineke Neutel},
  journal={Drug Safety},
Reports of corticosteroid-induced adverse psychiatric effects began to appear in the literature soon after the introduction of these medications in the 1950s. Unfortunately, early studies relied on informal classification and measurement procedures and tended to utilise nonspecific descriptive terminology (such as ‘steroid psychosis’). A growing number of contemporary investigations have begun to address these problems. However, the literature remains surprisingly undeveloped from a… 

Case of steroid induced mania

A 14-year-old female intermediate school student, with a recent diagnosis of Chron’s disease was brought to A&E department due to acute behavioral disturbance in form of confusion, visual hallucinations, psychomotor agitation, irritability, hyperactivity, talkativeness, lack of sleep, and physical aggression, and was diagnosed with steroid induced mania.

Steroid psychosis: a review for neurosurgeons

Atypical antipsychotic drugs like olanzapine and risperidone may cause fewer dystonic reactions and extrapyramidal symptoms than typical antipsychotics like haloperidol, and therefore, are often recommended as first line treatment.

Psychological and psychiatric sequelae of steroid use in Hematology treatments: A review of the literature

This review provides a starting point by outlining the present literature on the psychological and psychiatric impact of steroid use and outlining the priorities for further research into this area.

Risperidone treatment in a steroid-induced psychosis case -

A case of a 46-year-old man with a recent diagnosis of optic neuritis, who has psychotic symptoms which appear to be induced by steroids, which is suggested to be considerably higher than what has been reported in the current literature.

Risperidone Treatment in a Steroid-Induced Psychosis

It is suggested that the prevalence of steroid-induced psychiatric symptoms in patients with optic neuritis might be considerably higher than what has been reported in the current literature.


A case of psychosis in a case of erythema multiforme major treated with steroids that presented to psychiatric outpatient department requiring medical management is reported, emphasizing on the need of liaison-based approach for a holistic management in such cases.

Steroid-induced psychosis in an adolescent: treatment and prophylaxis with risperidone.

This is the first reported case of steroid-induced psychosis successfully treated with risperidone in an adolescent with nephrotic syndrome and Pediatricians should be aware of this rare problem when prescribing corticosteroids in this age group.

Corticosteroid-induced neuropsychiatric disorders: review and contrast with neuropsychiatric lupus

A dose-dependent relationship (increased risk when the daily prednisone-equivalent dose is ≥40 mg) has been observed in most cases of CIPD, although there have been case reports with lower doses, alternate-day therapy, and even inhaled CS.

Steroid induced Psychiatric Syndromes in Patients with Chronic Glomerulonephritis

The findings indicate that severe psychiatric reactions occur in approximately 2% of steroid-treated patients, and the large proportion of these patients have affective and/or psychotic symptoms, and treatment with steroid-taper, neuroleptics or electroconvulsive therapy with regard to the clinical status is generally effective in these patients.

Can "steroid switching" improve steroid-induced psychosis in a patient with advanced cancer?

The case of 67-year-old man with malignant pleural mesothelioma and pulmonary emphysema who developed psychiatric symptoms after switching from oral prednisolone 10 mg/ day to intravenous betamethasone 2 mg/day is experienced.



Effects of lithium on steroid-induced depression

‘Steroid Psychosis’: A Case Report

  • N. Baloch
  • Medicine, Psychology
    British Journal of Psychiatry
  • 1974
A picture of an organic confusional state is said to result from high doses and prolonged therapy with corticosteroids and ACTH, which is recognized to cause psychiatric sequelae more often than the cortic Fosteroids.

Corticosteroids in cancer: neuropsychiatric complications.

A more careful clinical delineation of the mental changes with steroids is desirable not only for the clinical relevance, but for the potential understanding of the etiology of mood disorders and mental changes seen in delirium.

BRIEF COMMUNICATION: Tricyclic Exacerbation Of Steroid Psychosis

Four patients in a series of 14 cases of steroid psychosis where steroids were used to treat disease not effecting the central nervous system, are reported. All demonstrated a predominantly affective

Presentation of the Steroid Psychoses

Patients receiving daily doses of 40 mg of prednisone or its equivalent, are at greater risk for developing steroid psychosis, and tricyclic antidepressants produced an exacerbation or worsening of the clinical state in all patients to whom they were administered.

Steroid-induced psychiatric disorders

Mechanisms of SIPDs are poorly understood, although there is increasing evidence to implicate disruption of catecholamine neurotransmission, and further clarification of aetiologic factors is needed if appropriate treatment strategies are to be developed for this relatively common group of disorders.

Exogenous corticosteroid effects on mood and cognition: case presentations.

  • M. D. ReckartS. Eisendrath
  • Medicine, Psychology
    International journal of psychosomatics : official publication of the International Psychosomatics Institute
  • 1990
Based on reports, the frequency of affective and cognitive side effects of exogenous corticosteroids may be much higher than has been previously reported.