Corticosteroid-Binding Globulin: A Review of Basic and Clinical Advances.

@article{Meyer2016CorticosteroidBindingGA,
  title={Corticosteroid-Binding Globulin: A Review of Basic and Clinical Advances.},
  author={Emily J. Meyer and Marni Anne Nenke and Wayne A. Rankin and John G. Lewis and David James Torpy},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2016},
  volume={48 6},
  pages={
          359-71
        }
}
Corticosteroid-binding globulin (CBG, transcortin) is the primary cortisol binding protein. It is a non-inhibitory serine protease inhibitor, capable of conformational change from a high cortisol-binding affinity form to a low affinity form upon cleavage of its reactive centre loop by various proteases, such as neutrophil elastase. The burgeoning inflammatory role of CBG applies to acute, severe inflammation where depletion is associated with mortality, and to chronic inflammation where defects… CONTINUE READING
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